IPDfromKM: reconstruct individual patient data from published Kaplan-Meier survival curves
نویسندگان
چکیده
منابع مشابه
Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves
BACKGROUND The results of Randomized Controlled Trials (RCTs) on time-to-event outcomes that are usually reported are median time to events and Cox Hazard Ratio. These do not constitute the sufficient statistics required for meta-analysis or cost-effectiveness analysis, and their use in secondary analyses requires strong assumptions that may not have been adequately tested. In order to enhance ...
متن کاملA Review and Comparison of Methods for Recreating Individual Patient Data from Published Kaplan-Meier Survival Curves for Economic Evaluations: A Simulation Study
BACKGROUND In general, the individual patient-level data (IPD) collected in clinical trials are not available to independent researchers to conduct economic evaluations; researchers only have access to published survival curves and summary statistics. Thus, methods that use published survival curves and summary statistics to reproduce statistics for economic evaluations are essential. Four meth...
متن کاملSurvival analysis I: the Kaplan-Meier method.
The Kaplan-Meier (KM) method is used to analyze 'time-to-event' data. The outcome in KM analysis often includes all-cause mortality, but could also include other outcomes such as the occurrence of a cardiovascular event. The purpose of this article is to explain the basic concepts of the KM method, to provide some guidance regarding the presentation of the KM results and to discuss some importa...
متن کاملThe Kaplan Meier Estimate in Survival Analysis
The need for analyzing time to event data arises in a number of applied fields, such as epidemiology, public health and medicine [1]. ‘Time to event’ simply means the time from entry into a study until a subject has a particular outcome. The study that involves time to event can be a cohort study on a specific number of patients or participants which should be followed for a particular time per...
متن کاملSurvival Analysis I: The Kaplan-Meier Method
The Kaplan-Meier (KM) method is used to analyze ‘time-toevent’ data. The outcome in KM analysis often includes allcause mortality, but could also include other outcomes such as the occurrence of a cardiovascular event. The purpose of this article is to explain the basic concepts of the KM method, to provide some guidance regarding the presentation of the KM results and to discuss some important...
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ژورنال
عنوان ژورنال: BMC Medical Research Methodology
سال: 2021
ISSN: 1471-2288
DOI: 10.1186/s12874-021-01308-8